Skip to main content

Oklahoma: The 3-Drug Death Penalty Cocktail is a Mess

If you want ammunition against America's death penalty, read two reports in Friday's New York Times about the latest execution in Oklahoma. One is a grim description of what happened when Clayton Lockett was given a lethal injection on Tuesday, the other an analysis of the common 3-drug protocol used to kill Lockett and inmates in several other states.

Since Lockett died of a heart attack 43 minutes into the botched attempt to kill him, it's been revealed that he was actually tasered for resisting the preliminary X-rays apparently required for execution. That's the 1st time any condemned prisoner has been shocked before they've been injected. Further, the initial reports that a vein in Lockett's arm collapsed were untrue. Instead, a phlebotomist or a doctor - it's not clear which one, but doctors aren't supposed help with executions - tried to insert a line into Lockett's femoral vein, which is in the groin. That's a dicey thing to do, and apparently failed, leaking drugs into his tissues:

But Oklahoma officials said that problems with the IV delivery, not the drugs themselves, accounted for Tuesday night's problems.

Anesthesiologists said that while they sometimes use a femoral vein accessible from the groin when those in the arms and legs are not accessible, the procedure is more complicated and potentially painful.

Putting a line in the groin "is a highly invasive and complex procedure which requires extensive experience, training and credentialing," said Dr. Mark Heath, an anesthesiologist at Columbia University. Oklahoma does not reveal the personnel involved in executions.

"There are a number of ways of checking whether a central line is properly placed in a vein, and had those been done they ought to have known ahead of time that the catheter was improperly positioned," Dr. Heath said.

Dr. Joel Zivot, an anesthesiologist at the Emory University School of Medicine, said that the prison's initial account that the vein had collapsed or blown was almost certainly incorrect.

"The femoral vein is a big vessel," Dr. Zivot said. Finding the vein, however, can be tricky. The vein is not visible from the surface, and is near a major artery and nerves. "You can't feel it, you can't see it," he said.

Without special expertise, Dr. Zivot said, the failure was not surprising.

And what's below is an understatement:

David Dow, a death penalty appellate lawyer in Texas, said that prisoners sometimes resist leaving their cells, but that "it's not something that happens regularly." He expressed surprise that the medical staff administering the drugs did not have a 2nd vein ready in case of problems with the 1st. "For a state that executes people," he said, "they are awfully bad at it."

This has been a mess. Not only was the execution botched, perhaps by incompetent technicians or doctors, but Oklahoma has been releasing incorrect information on what happened, and correcting it only bit by bit. The state should have waited for a full investigation, and then made it absolutely public. The secrecy is unwarranted.

If Lockett's execution isn't "cruel and unusual punishment" - a violation of the Constitution's Eighth Amendment - I don't know what is. Because high-quality American and foreign pharmacies refuse to furnish drugs for this form of retributive execution, there's not much quality control, and no guarantee of the dosage and purity of the drugs used (Oklahoma, of course, refuses to release that information and the source of the drugs). Also cruel and unusual is the customary use of 3 drugs in sequence instead of just one.

The Times's other article addresses the obvious question: do we really need to use three drugs given that large animals are peacefully euthanized with a single chemical (many of us have done this to our pets), and terminal patients in Switzerland go gently after a single drink of pentobarbital? Doctors in other places will often give an overdose of morphine to terminal patients, knowing it will kill them. Clearly, a single drug - a barbiturate - will suffice, and in fact has been used in several states:

Physicians have long known that large doses of single drugs - certain sedatives or anesthetics - can take a life painlessly, and with far less distress than the 3-drug cocktail causes if the injection is botched.

Since 2010, more death-penalty states - Oklahoma not among them - have moved to use single drugs for lethal injection. Even critics of the death penalty say most of those executions have gone more smoothly than ones involving multiple drugs.

Barbiturates, including sodium thiopental and pentobarbital, infused into the bloodstream can quickly make a person go deeply unconscious, stop breathing and die. Dr. Mark J. Heath, an anesthesiologist at Columbia University and an expert on lethal injection, said that high doses of pentobarbital were routinely used to euthanize animals, from pet rabbits to beached whales.

Barbiturates alone have been used in 71 executions, in Arizona, Georgia, Idaho, Missouri, Ohio, South Dakota, Texas and Washington, said Jennifer Moreno, a lawyer with the Death Penalty Clinic at Berkeley Law School.

Even though Dr. Heath opposes lethal injection, he said, "I have not seen a single complaint, not an unhappy warden or family or anybody, from the single-drug barbiturate approach."

The 3-drug cocktail is a mess. The 1st one is supposed to render you unconscious, the 2nd paralyzes your breathing muscles, and the 3rd stops your heart. But if the 1st one doesn't work well, you'll be conscious while the 2nd and 3rd do their things, which can be horribly painful if you're conscious.

So why are we even using the 3-drug protocol? Apparently from inertia alone. The cocktail was developed in 1977 by Dr. Jay Chapman, Oklahoma's medical examiner, and has been continued simply out of habit. In fact, Chapman now maintains that he'd recommend a single injection of barbiturate instead.

The problem is not just that, though: it's also that the drugs are given intravenously, with needles inserted by people who don't seem to know what they are doing. The 3-drug sequence can be eliminated in favor of a single more humane injection, and the drug doses can perhaps be fixed. But what can't be fixed is the inexperience of people inserting the lines, and the absence of doctors supervising the process (it is rightly considered unethical for a physician to do more at an execution than pronounce the inmate dead). What also can't be done is to resurrect an executed inmate who is innocent. A new report in the Proceedings of the National Academy of Sciences suggests that more than 4% of people on death row were convicted falsely. It goes without saying that once you're dead, exculpation is useless. Are we willing to accept a figure of 1 in 25 prisoners being killed by mistake?

Further, like innocent people sentenced to death, bungled executions aren't uncommon. The Death Penalty Information Center tallies 44 botched executions since 1977, when U.S. states began killing people again after a decade's respite. Have a look, but be warned that the descriptions are graphic and horrible. But if you're in favor of the death penalty, even by lethal injection, you're obligated to see how things can go wrong.

Yet there are alternatives that get the state out of the killing business, allowing someone falsely convicted to go free. These alternatives are also cheaper than execution, which is always preceded by long and complicated legal battles. A common substitute is a sentence of life without parole in prison or a psychiatric facility. But while that may be necessary for incorrigible offenders, or those who have incurable mental illness, we shouldn't automatically see it as the best alternative to a death sentence. In countries like England, nearly all life sentences include at least a possibility of parole after a long stint in jail. In contrast, in the U.S. every prisoner sentenced to life without parole has died in prison. Are we certain there's a benefit in keeping old people locked up?

If you're a determinist like me who feels that criminals, acting under the influence of their genes and environments, simply had no choice about committing their crime, then you see only 3 rationales for punishment. These are deterrence, rehabilitation, and removal of offenders from society. Retribution isn't included since it does nothing but cater to an outmoded desire for revenge. And even if you're not a determinist, government-sanctioned revenge killing simply isn't rational.

None of the 3 goals are met by capital punishment, and maybe not by automatic life-without-parole sentences, either. If you don't think a murderer had a free "choice" about what he did, then you must rethink how to deal with his transgression. The reason we don't figure out what forms of punishment are optimal for deterring others, rehabilitating offenders, or keeping them away from society until they become harmless, is because those things are hard to do. They take empirical study - scientific analysis. But this is what we must do if our judicial system is to be both rational and humane, and fall in line with every other First World country (except Japan) that eschews executions. What we shouldn't do is keep inflicting cruelty simply because that's what we've always done.

Source: Op-ed by Jerry A. Coyne. Mr. Coyne is a professor of Ecology and Evolution at The University of Chicago, May 2014

Most viewed (Last 7 days)

Florida executes Chadwick Scott Willacy

STARKE, Fla. -- A Florida man who set his neighbor on fire after she returned from work to find him burglarizing her home was executed Tuesday evening. Chadwick Scott Willacy, 58, received a three-drug injection and was pronounced dead at 6:15 p.m. at Florida State Prison near Starke for the 1990 killing of Marlys Sather. It was Florida's fifth execution this year. The curtain to the execution chamber went up promptly at the scheduled 6 p.m. time, and the lethal injection got underway two minutes later, after Willacy made a brief statement.

Florida | Man avoids death penalty in Daytona Beach triple murder

Jerome Anderson shot and killed Antoine Melvin, 42, John Burch, 65, and Patrick Lassiter, 35, in 2023. A man pleaded no contest to a triple-murder in Daytona Beach and was sentenced April 20 to three consecutive life terms in prison as part of a plea deal in which he avoided a possible death sentence. Jerome Anderson, 41, was indicted on three counts of first-degree murder and possession of a firearm by a convicted felon in the 2023 triple-slaying. Anderson pleaded no contest to the three first-degree murder charges April 20 and, in exchange, Assistant State Attorney Andrew Urbanak agreed not to continue to pursue the death penalty.

Florida Schedules Two Executions for Late April

TALLAHASSEE, Fla. — Governor Ron DeSantis has directed the Florida Department of Corrections to move forward with two executions scheduled for late April 2026, marking a significant ramp-up in the state's use of capital punishment. The scheduled deaths of Chadwick Willacy and James Ernest Hitchcock follow a series of landmark judicial rulings that have kept both men on death row for decades.

20 Minutes to Death: Witness to the Last Execution in France

The following document is a firsthand account of the final moments of Hamida Djandoubi, a convicted murderer executed by guillotine at Marseille’s Baumettes Prison on September 10, 1977. The record—dated September 9—was written by Monique Mabelly, a judge appointed by the state to witness the proceedings. Djandoubi’s execution would ultimately be the last carried out in France before capital punishment was abolished in 1981. At the time, President Valéry Giscard d'Estaing—who had publicly voiced his "deep aversion to the death penalty" prior to his election—rejected Djandoubi’s appeal for clemency. Choosing to let "justice take its course," the President allowed the execution to proceed, just as he had in two previous cases during his term:   Christian Ranucci , executed on July 28, 1976 and Jérôme Carrein , executed on June 23, 1977. Hamida Djandoubi , a Tunisian national, was sentenced to death for killing his former lover, Elisabeth Bousquet. He was execu...

Iran to execute first woman linked to mass protests after ‘forced confessions’

Bita Hemmati and three others have been sentenced to death for 'collusion' and 'propaganda.' Advocates claim the charges are baseless, citing a secretive process and state-televised interrogations. Iranian authorities are preparing to execute Bita Hemmati, the first woman sentenced to death in connection with the mass protests in Tehran in late December and January, according to the US-based non-profit the Human Rights Activists News Agency. Judge Iman Afshari, of Branch 26 of the Tehran Revolutionary Court, sentenced Hemmati, her husband, Mohammadreza Majidi Asl, and Behrouz Zamaninezhad, and Kourosh Zamaninezhad to death on the charge of “operational action for the hostile government of the United States and hostile groups,” in addition to discretionary imprisonment period of five years on the charge of “assembly and collusion against national security.”  

Arizona | Man who murdered pastor crucifixion style requests plea deal after parents killed in plane crash

Adam Sheafe, the California man who admitted to killing a New River, Arizona, pastor in a crucifixion-style attack, has asked prosecutors to offer him a plea deal that would result in a natural life sentence rather than the death penalty he had previously sought. Advisory council attorneys representing Sheafe sent a formal plea offer to prosecutors this week, about two weeks after his father and stepmother died in a plane crash at Marana Airport on April 8, according to 12 News. Sheafe, 51, is charged with first-degree murder in the death of William Schonemann, 76, pastor of New River Bible Church, who was found dead inside his home last April.

Singapore executes man for trafficking 1kg of cannabis

SINGAPORE — Singaporean authorities executed Omar bin Yacob Bamadhaj at Changi Prison on Thursday, April 16, 2026, following his 2019 conviction for importing 1,009.1 grams of cannabis. Bamadhaj, 41, though some reports have cited his age as 46, was arrested on July 12, 2018, during a routine search at the Woodlands Checkpoint. Officers discovered the narcotics wrapped in plastic and hidden within his vehicle as he attempted to enter Singapore from Malaysia.  Under the Misuse of Drugs Act, the threshold for the mandatory death penalty involving cannabis is 500 grams, a limit this shipment exceeded by more than double.

Tennessee | Man set to be executed files motion claiming DNA evidence will exonerate him

MEMPHIS, Tenn. — Attorneys for death row inmate Tony Carruthers filed a motion in Shelby County Criminal Court seeking immediate DNA testing on evidence they claim will prove his innocence in a 1994 triple murder.  Carruthers is scheduled for execution on May 12. He was convicted and sentenced to death for the kidnapping and murders of 24-year-old Marcellos Anderson, 17-year-old Delois Anderson, and 21-year-old Frederick Scarborough. Prosecutors at trial alleged the victims were buried alive in a Memphis cemetery as part of a drug-related robbery.

US Department of Justice announces decision to resume federal executions

The Department of Justice (DOJ) announced on Friday that it will resume the federal use of capital punishment and that it is seeking death sentences against 44 defendants. DOJ also said that it will use firing squads, electrocution, or nitrogen asphyxiation if the drug used in lethal injection is unavailable. The announcement follows the Restoring and Strengthening the Federal Death Penalty report, published on April 24. The report is especially critical of the moratorium on federal executions, ordered by Attorney General Merrick Garland in July 2021, to remain until the death penalty could be conducted “fairly and humanely.” Garland was concerned about the federal lethal injection protocol, which uses only one drug, pentobarbital, and the possibility that it causes “unnecessary pain and suffering.” In response to Garland’s moratorium and concerns, President Biden commuted the sentences of 37 prisoners on federal death row, leaving only three prisoners.

Florida Supreme Court upholds death sentence for man who raped & killed girl, babysitter in 1990

FORT MYERS, Fla. — The Florida Supreme Court on Friday affirmed the convictions and death sentences of Joseph Zieler for the 1990 murders of an 11-year-old girl and her babysitter, clearing the way for his execution after decades of the case remaining unsolved. Zieler, 61, was sentenced to death in 2023 for the slayings of Robin Cornell and Lisa Story. The decision by the state’s highest court marks a pivotal moment in one of Southwest Florida’s most notorious cold cases, which saw no progress until a 2016 DNA match linked Zieler to the crime scene.