Skip to main content

Oklahoma | Doctors question sedative dose used in execution

While medical experts say it’s unclear why an Oklahoma inmate began convulsing and vomiting after the first of three drugs used to execute him was administered, all agree the dosage was massive compared with what’s standard in surgeries — with one doctor calling it “insane.”

The state’s prisons agency is now likely to face new litigation, which may focus on the state’s description of the execution of John Marion Grant for the 1998 slaying of a prison cafeteria worker as “in accordance with” protocols.

Grant, 60, convulsed and vomited after the sedative midazolam was administered. That drug was followed by two more: vecuronium bromide, a paralytic, and potassium chloride, which stops the heart.

Thursday’s lethal injection ended a six-year moratorium on executions in Oklahoma that was brought on by concerns over its execution methods, including prior use of midazolam.

Oklahoma’s protocols call for administering 500 milligrams of the sedative. 


Arkansas and Ohio are among other states that use that dose of midazolam in executions.

“It’s just an insane dose and there’s probably no data on what that could cause,” said Jonathan Groner, an Ohio State University medical school surgery professor and lethal injection expert.

He added that sedation does not increase as the dosage goes up.

“There’s a reason these drugs are given by anesthesiologists and not prison guards,” he said.

Grant was strapped to a gurney inside the execution chamber when the drugs were administered. After several minutes, two members of the execution team wiped the vomit from his face and neck. He was declared unconscious about 15 minutes after receiving the first drug and declared dead about six minutes after that, at 4:21 p.m.

In a statement released immediately after the execution, state prisons spokesman Justin Wolf said it “was carried out in accordance with Oklahoma Department of Corrections’ protocols and without complication.”

On Friday, prisons director Scott Crow said it was “without complication” because there was no interruption of the agency’s process for putting someone to death. He said Grant’s vomiting “was not pleasant to watch, but I do not believe it was inhumane.”

Crow said the doctor monitoring the execution said Grant was unconscious when he was vomiting and that “regurgitation is not a completely uncommon instance or occurrence with someone who is undergoing sedation.”

Dr. Karen Sibert, an anesthesiologist and professor at the University of California, Los Angeles, disputed that, saying that type of nausea is not normally associated with the class of drugs that includes midazolam. A lack of oxygen could have brought on the convulsions, along with Grant’s high levels of anxiety and distress, she said.

“Midazolam does not usually cause it by itself,” Sibert said.

Even before Grant’s execution, more than than two dozen Oklahoma death row inmates were part of a federal lawsuit challenging the state’s lethal injection protocols, arguing that the three-drug method risks causing unconstitutional pain and suffering. 

A trial is set for early next year.


The state almost surely will face new lawsuits over its execution protocols, said Robert Denham, executive director of the Death Penalty Information Center, a capital punishment clearing house that opposes the death penalty. The Corrections Department’s statement indicating that the execution wasn’t botched could provide proof of the protocols’ unconstitutionality, said Denham.

“Either they lied to the public and they can’t be trusted or they told the truth and the protocol can’t be trusted,” Denham said.

Grant was the first person in Oklahoma to be executed since a series of flawed lethal injections in 2014 and 2015. He was serving a 130-year prison sentence for several armed robberies when witnesses say he dragged prison cafeteria worker Gay Carter into a mop closet and stabbed her 16 times with a homemade shank.

States turned to midazolam over the past decade after supplies of more powerful barbiturates such sodium thiopental disappeared or companies made them unavailable following pressure from death penalty opponents. 

Even death penalty opponents agreed such a drug wouldn’t cause pain.

Midazolam has been associated with other troublesome executions, with accounts of inmates snorting and gasping following its administration, or coughing loudly, or their stomachs inflating and deflating.

In April 2014, Oklahoma inmate Clayton Lockett struggled on a gurney before dying 43 minutes into his lethal injection during the state’s first use of midazolam — and after the state’s prisons chief ordered executioners to stop.

Oklahoma halted executions in 2015 after other problematic lethal injections. 

While the moratorium was in place, Oklahoma moved ahead with plans to use nitrogen gas to execute inmates, but ultimately scrapped that idea and announced last year that it planned to resume executions using the same three-drug lethal injection protocol that was used during the flawed executions.

In 2015, a divided U.S. Supreme Court said Oklahoma’s use of midazolam didn’t violate the Constitution’s Eighth Amendment prohibition on cruel and unusual punishment. The court also said “some risk of pain is inherent in any method of execution.”

But Denham notes that the court said inmates challenging its use hadn’t proved it was unconstitutional, not that the drug itself was constitutional.

Oklahoma has six more executions scheduled to take place through March, and prison officials say they have confirmed a source to supply all the drugs needed.

Source: The Associated Press, Staff, October 29, 2021


🚩 | Report an error, an omission, a typo; suggest a story or a new angle to an existing story; submit a piece, a comment; recommend a resource; contact the webmaster, contact us: deathpenaltynews@gmail.com.


Opposed to Capital Punishment? Help us keep this blog up and running! DONATE!



"One is absolutely sickened, not by the crimes that the wicked have committed,
but by the punishments that the good have inflicted." -- Oscar Wilde

Most viewed (Last 7 days)

Louisiana's First Nitrogen Execution Reflects Broader Method Shift

Facing imminent execution by lethal gas earlier this week, Jessie Hoffman Jr. — a Louisiana man convicted of abducting, raping and murdering a 28-year-old woman in 1996 — went to court with a request: Please allow me to be shot instead. In a petition filed with the U.S. Supreme Court on March 16 seeking a stay of his execution by nitrogen hypoxia, a protocol that had yet to be tested in the state, Hoffman requested execution by firing squad as an alternative.

Bangladesh | Botswana Woman Executed for Drug Trafficking

Dhaka, Bangladesh – Lesedi Molapisi, a Botswana national convicted of drug trafficking, was executed in Bangladesh on Friday, 21 March 2025. The 31-year-old was hanged at Dhaka Central Jail after exhausting all legal avenues to appeal her death sentence. Molapisi was arrested in January 2023 upon arrival at Hazrat Shahjalal International Airport in Dhaka, where customs officials discovered 3.1 kilograms of heroin hidden in her luggage. Following a trial under Bangladesh’s Narcotics Control Act, she was sentenced to death in May 2024. Her execution was initially delayed due to political unrest in the country but was carried out last week.

Oklahoma executes Wendell Grissom

Grissom used some of his last words on Earth to apologize to everyone he hurt and said that he prays they can find forgiveness for their own sake. As for his execution, he said it was a mercy. Oklahoma executed Wendell Arden Grissom on Thursday for the murder of 23-year-old Amber Matthews in front of her best friend’s two young daughters in 2005.  Grissom, 56, was executed by lethal injection at the Oklahoma State Penitentiary in McAlester and pronounced dead at 10:13 a.m. local time, becoming the first inmate to be put to death by the state in 2025 and the ninth in the United States this year. 

Louisiana executes Jessie Hoffman Jr.

Louisiana used nitrogen gas Tuesday evening to execute a man convicted of murdering a woman in 1996, the 1st time the state has used the method, a lawyer for the condemned man said.  Jessie Hoffman Jr., 46, was put to death at the Louisiana State Penitentiary, defense lawyer Cecelia Kappel said in a statement. He was the 1st person executed in the state in 15 years, and his death marked the 5th use of the nitrogen gas method in the US, with all the rest in Alabama.  Hoffman was convicted of the murder of Mary "Molly" Elliott, a 28-year-old advertising executive. At the time of the crime, Hoffman was 18.

Supreme Court rejects appeal from Texas death row inmate

WASHINGTON (AP) — The Supreme Court on Monday rejected an appeal from a Texas death row inmate whose bid for a new trial drew the support of the prosecutor’s office that originally put him on death row. The justices left in place a Texas appeals court ruling that upheld the murder conviction and death sentence for Areli Escobar, even though Escobar’s case is similar to that of an Oklahoma man, Richard Glossip, whose murder conviction the high court recently overturned.

South Carolina | Spiritual adviser of condemned inmate: 'We're more than the worst thing we've done'

(RNS) — When 67-year-old Brad Sigmon was put to death on March 7 in South Carolina for the murder of his then-girlfriend's parents, it was the first time in 15 years that an execution in the United States had been carried out by a firing squad. United Methodist minister Hillary Taylor, Sigmon's spiritual adviser since 2020, said the multifaceted, months long effort to save Sigmon's life, and to provide emotional and spiritual support for his legal team, and the aftermath of his execution has been a "whirlwind" said Taylor, the director of South Carolinians for Alternatives to the Death Penalty.

Florida executes Edward James

Edward James received 3-drug lethal injection under death warrant signed in February by governor Ron DeSantis  A Florida man who killed an 8-year-old girl and her grandmother on a night in which he drank heavily and used drugs was executed on Thursday.  Edward James, 63, was pronounced dead at 8.15pm after receiving a 3-drug injection at Florida state prison outside Starke under a death warrant signed in February by Governor Ron DeSantis. The execution was the 2nd this year in Florida, which is planning a 3rd in April. 

Texas Death Row chef who cook for hundreds of inmates explained why he refused to serve one last meal

Brian Price would earn the title after 11 years cooking for the condemned In the unlikely scenario that you ever find yourself on Death Row, approaching your final days as a condemned man, what would you request for your final meal? Would you push the boat out and request a full steal dinner or play it safe and opt for a classic dish such as pizza or a burger? For most of us it's something that we'll never have to think about, but for one man who spent over a decade working as a 'Death Row chef' encountering prisoner's final requests wasn't anything out of the ordinary.

'No Warning': The Death Penalty In Japan

Stakes for wrongful convictions are high in Japan, where the death penalty has broad public support despite criticism over how it is carried out. Tokyo: Capital punishment in Japan is under scrutiny again after the world's longest-serving death row prisoner, Iwao Hakamada, was awarded $1.4 million in compensation this week following his acquittal last year in a retrial. Stakes for wrongful convictions are high in Japan, where the death penalty has broad public support despite international criticism over how it is carried out.

South Carolina plans to carry out a firing squad execution. Is it safe for witnesses?

South Carolina plans to execute a man by firing squad on March 7, the first such execution in the state and the first in the nation in 15 years. But firearms experts are questioning whether South Carolina's indoor execution setup is safe for the workers who will shoot the prisoner and the people who will watch. Photos released by the South Carolina Department of Corrections show that the state intends to strap the prisoner, Brad Sigmon, to a metal seat in the same small, indoor brick death chamber where South Carolina has executed more than 40 other prisoners by electric chair and lethal injection since 1985.